A novel excipient for oral bioavailability
A specialty pharma company needed a new excipient to improve the oral bioavailability of a poorly soluble drug candidate.
The compound’s low solubility was limiting absorption and threatening the viability of an oral formulation.
Known excipient platforms had already failed to deliver the required uplift.
Mapped the available solubility enhancement pathways and the full landscape of enabling excipients.
Searched worldwide including adjacent fields such as nutraceuticals and agrochemicals for novel delivery technologies.
Assessed candidates for performance, IP position and regulatory acceptability.
Identified a novel excipient platform from a university spin-out.
Demonstrated a threefold increase in oral bioavailability in early testing.
Facilitated a licensing conversation between the client and the innovator.
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