Technology (UPN: 40)
|A bacteriophage lysates production technology|
|Organisation Region||Middle East|
|Overview||A method for the commercial production of bacteriophages composition. The method decreases the production volume and increases the production yields.|
The innovative phage production process enables the following competitive advantages over conventional phage production by liquid fermentation:
Topical phage ointments, Gasto-intestinal phage capsules, Acne protection phage Ointment, Dental phage products, Phage Probiotic adjuvant, Food Safety Phages food additives and surface treatment agents, Aquaculture Phages, E.coli Phage agent for livestock, Campylobacter phage, Crop protection phage agents, Fermentation control phages
Conventional liquid fermentation of phage lysates is limited: • Large fermentors are expensive and bulky • Liquid fermentation is prone to contamination from external microbes resulting in lost production batches and long down time for sanitation • Fermentors are dedicated to single strain bacteria/phage at a time and require long and complex cleaning and validation procedures • Final titer is limited to 10^7 to 10^8 PFU (Plaque Forming Unit) • Yield is limited by fermentors capacity Conventional micro-filtration affects yield and quality because : 1) Remaining soluble debris is allergen and prohibited by regulation 2) Loss of several logs in titer • High production cost of over $10 / Gallon • Large qualitative and quantitative variations in batches
In user / Testing result available
US Patent granted in 2009
|Innovator||A company that develops technologies for the production of bacteriophages-based anti-bacterials for a range of clinical and animal applications.|
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