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45 Aptamer-Based Therapeutics
The Innovator’s technology blocks the 3’ end of aptamers and other DNA oligonucleotides (e.g., antisense DNA) with proteins to stabilize these potentially therapeutic molecules in the body. The proteins can be simple serum albumins or more functional proteins such as the Fc tails of IgG antibodies or C1q to trigger the immune (complement) system to opsonize (phagocytize) or punch holes in cancer cells, Gram negative antibiotic-resistant bacteria and parasites. Specific aptamer sequences can also be used to coat deadly viruses such as West Nile and dengue viruses to curb their progression in vivo.
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