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UPN Ref Technology
45 Aptamer-Based Therapeutics
The Innovator’s technology blocks the 3’ end of aptamers and other DNA oligonucleotides (e.g., antisense DNA) with proteins to stabilize these potentially therapeutic molecules in the body. The proteins can be simple serum albumins or more functional proteins such as the Fc tails of IgG antibodies or C1q to trigger the immune (complement) system to opsonize (phagocytize) or punch holes in cancer cells, Gram negative antibiotic-resistant bacteria and parasites. Specific aptamer sequences can also be used to coat deadly viruses such as West Nile and dengue viruses to curb their progression in vivo.
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44 DNA Aptamers and Aptamer-Based Diagnostics
The Innovator is selling some of its patented or patent-pending aptamers to the public R&D community. The Innovator has also leveraged funds to produce a new portable (G2 FLASH) reader for its DNA aptamer-magnetic bead sandwich and FRET-aptamer assays. The assays are either developed already or are in development for the major foodborne pathogenic bacteria (Campylobacter, E. coli O157:H7, Salmonella, and Listeria) and clinical analytes such as bone loss (osteoporosis) and cardiovascular markers.
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40 A bacteriophage lysates production technology
A method for the commercial production of bacteriophages composition. The method decreases the production volume and increases the production yields.
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38 Nanopore technology platform
A nanopore technology platform that enables high-throughput measurements of particles as they passes through a pore. The highly precise analytical nanotechnology uses tunable nanopore-based measurement to rapidly determine the size, charge and concentration of particle populations with individual particle resolution.
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28 Natural fungal-based preservative candidate
A natural preservative candidate that inhibites the growth of yeasts and molds in the pH range < 5.
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26 Natural-based deodorant additive ingredient
An extract from a good accessible edible plant biomaterial that shows a novel biological mode of action by inhibition the microbiological biofilm formation in the underarm region of the human body. It is scientific proved that the bacterial growth responsible for malodor is reduced by the active principle. The extract has been modified in such a way it can inhibit bacterial growth for at least 24 hours.
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7 In vitro 3D skin model technology
A highly reproducible full thickness primary human skin equivalent, uniquely capable of the surface growth of skin microorganisms in their natural state. It is used as a high-grade research platform for the testing of active ingredients and topical formulations for claims support in all areas of dermatology, skin care and cosmetics. The highly defined structure and responsive biology provides opportunities for far more sophisticated and predictive experimentation than simpler, less capable models and human and porcine ex-vivo materials.
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