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UPN Ref Technology
45 Aptamer-Based Therapeutics
The Innovator’s technology blocks the 3’ end of aptamers and other DNA oligonucleotides (e.g., antisense DNA) with proteins to stabilize these potentially therapeutic molecules in the body. The proteins can be simple serum albumins or more functional proteins such as the Fc tails of IgG antibodies or C1q to trigger the immune (complement) system to opsonize (phagocytize) or punch holes in cancer cells, Gram negative antibiotic-resistant bacteria and parasites. Specific aptamer sequences can also be used to coat deadly viruses such as West Nile and dengue viruses to curb their progression in vivo.
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38 Nanopore technology platform
A nanopore technology platform that enables high-throughput measurements of particles as they passes through a pore. The highly precise analytical nanotechnology uses tunable nanopore-based measurement to rapidly determine the size, charge and concentration of particle populations with individual particle resolution.
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35 Advanced in-vitro model to evaluate the disposition and bio-performance of oral pharmaceuticals and nutritional products.
A dynamic in-vitro system that fully replicates the complex biochemical conditions and the array of gastric forces crucial for the prediction of the bio-performance of pharmaceuticals and nutritional based materials.
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